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Updated: Sep 30, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis]
Xiuping Han1, Ning Zhai, Qingrui Zhang
1Department of Dermatology, the First Hospital, China Medical University, Shenyang, Liaoning, 110001 P.R.China. nzhai@sina.com
Objective:
To evaluate further the nature of HLA-DQB1 alleles association with dermatomyositis/polymyositis (DM/PM).
Methods:
HLA-DQB1 typing of 52 patients with DM/PM were investigated by polymerase chain reaction-sequence specific primer method, and the frequencies of HLA-DQB1 alleles were compared.
Results:
It was found that the patients with DM/PM had significantly increased frequency of HLA-DQB1*0401(RR=3.56, P=1.79 10(-3), Pc<0.05).
Conclusion:
The results suggest that HLA-DQB1*0401 gene contribute to genetic susceptibility to DM/PM.
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