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Updated: Sep 30, 2026

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Published on: August 13, 2019
Effects of oral contraceptives with low-dose estrogen and desogestrel on leptin concentrations
Nevin Sağsöz1, Fatih Akçay, Merih Bayram
1Department of Obstetrics and Gynecology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey. nsagsoz@isbank.net.tr
Objective:
To evaluate short-term leptin concentrations in women who use low-dose oral contraceptives.
Study Design:
From 15 women without medical problems, venous blood samples were taken: basal, between days 3 and 5 of menstruation, and in the third month. The Human Leptin Radioimmunassay Kit (Linco Research, Inc., St. Charles, Missouri) was used for leptin measurement. Statistical analysis was done with the Wilcoxon test.
Results:
The average patient age was 30.1 +/- 6.7 years. The basal leptin concentrations and leptin concentrations at the third month were 22.17 +/- 8.85 and 23.04 +/- 6.77 ng/mL, respectively. This increase was not statistically significant.
Conclusion:
Oral contraceptives with low-dose estrogen and desogestrel do not affect leptin concentrations in a three-month period.
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