Related Experiment Video
Updated: Sep 9, 2026

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 3. Aerobiology
Published on: October 3, 2016
[Surveillance systems for early detection and mapping of the spread of morbidity caused by bioterrorism]
Manfred S Green1, Zalman Kaufman
1Sackler Faculty of Medicine, Tel Aviv University.
Abstract:
The early clinical presentations of many infectious diseases, including those initiated by bioterrorism, tend to have non-specific features such as flu-like symptoms, skin rashes, encephalitis and acute flaccid paralysis. Standard public health infectious disease surveillance systems depend on reports of specifically diagnosed diseases and thus may be relatively insensitive to the early identification of outbreaks. During the past few years, efforts have been made to improve the sensitivity of traditional systems, partly through implementation of new technologies such as electronic reporting and use of geographical information systems. In the United States, intensive efforts are being made to develop new surveillance systems for the early detection and mapping of the spread of diseases caused by bioterrorism. The development of such systems is based on the concept that surveillance for non-specific syndromes will enable earlier detection of infectious disease outbreaks compared with traditional systems. In addition, surveillance for non-specific syndromes could enable monitoring of the spread the outbreak, even before a definitive diagnosis has been made. In this paper, we describe several examples of prototype syndrome surveillance systems developed in the United States. These include the telephone hot-line system maintained by the New York City public health department, two internet based systems, LEADERS and RSVP, and an electronic reporting system, ESSENCE, operating in military facilities in the Washington DC area.
Insights
Syndrome surveillance systems detect infectious disease outbreaks earlier than traditional methods by monitoring non-specific symptoms. These systems are crucial for early detection and mapping of bioterrorism threats.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Context:
- Traditional infectious disease surveillance relies on specific diagnoses, potentially delaying outbreak detection.
- Bioterrorism and other infectious agents often present with non-specific, flu-like symptoms.
- Existing surveillance systems may lack sensitivity for early outbreak identification.
Purpose:
- To improve the sensitivity of infectious disease surveillance systems.
- To enable earlier detection and mapping of disease outbreaks, including bioterrorism.
- To evaluate prototype syndrome surveillance systems for public health applications.
Summary:
- Syndrome surveillance monitors non-specific symptoms for earlier detection of infectious disease outbreaks.
- New technologies like electronic reporting and GIS enhance traditional surveillance.
- Prototype systems in the US include hot-line, internet-based (LEADERS, RSVP), and electronic reporting (ESSENCE) models.
Impact:
- Enables earlier detection of outbreaks before definitive diagnoses are made.
- Facilitates real-time monitoring of disease spread.
- Enhances preparedness and response capabilities for public health emergencies.
Related Concept Videos
Steps in Outbreak Investigation
Principles of Disease Surveillance
Infectious Diseases and Their Occurrence
Investigation of Disease Outbreaks
Rapid Identification of Pathogens
Automated Microbial Diagnostics

