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Baeyer-Villiger oxidation in compressed CO2.

Carsten Bolm1, Chiara Palazzi, Giancarlo Franciò

  • 1Institut für Organische Chemie der RWTH Aachen, Professor Pirlet-Str. 1, D-52056, Aachen, Germany. Carsten.Bolm@oc.rwth-aachen.de

Chemical Communications (Cambridge, England)
|August 13, 2002
PubMed
Summary

This study demonstrates an efficient aerobic Baeyer-Villiger oxidation using compressed carbon dioxide. Aldehydes act as co-reductants for converting ketones to esters and lactones.

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Area of Science:

  • Organic Chemistry
  • Green Chemistry

Background:

  • The Baeyer-Villiger oxidation is a key transformation for synthesizing esters and lactones.
  • Traditional methods often require harsh reagents or specific conditions.

Purpose of the Study:

  • To develop an efficient and environmentally friendly method for the aerobic Baeyer-Villiger oxidation.
  • To explore the use of compressed carbon dioxide as a reaction medium.

Main Methods:

  • Aerobic Baeyer-Villiger oxidation of various cyclic and acyclic ketones.
  • Utilizing compressed carbon dioxide as the reaction solvent.
  • Employing an aldehyde as a co-reductant.

Main Results:

  • Efficient conversion of a wide range of ketones to their corresponding esters or lactones.

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  • Successful application of compressed carbon dioxide as a reaction medium.
  • Aldehyde co-reductant facilitates the aerobic oxidation process.

    • Conclusions:

    • Compressed carbon dioxide provides an effective medium for aerobic Baeyer-Villiger oxidation.
    • This method offers a greener alternative for ester and lactone synthesis.
    • The use of aldehydes as co-reductants is a viable strategy for this transformation.