Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structured treatment interruption: important controlled trial in monkeys.

J S James

    AIDS Treatment News
    |August 13, 2002
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ability of palatable food consumption to buffer against the short- and long-term behavioral consequences of social defeat exposure during juvenility in rats.

    Physiology & behavior·2017
    Same author

    Effects of electroconvulsive seizures on depression-related behavior, memory and neurochemical changes in Wistar and Wistar-Kyoto rats.

    Progress in neuro-psychopharmacology & biological psychiatry·2014
    Same author

    The effects of rewarding ventral tegmental area stimulation and environmental enrichment on lipopolysaccharide-induced sickness behavior and cytokine expression in female rats.

    Brain research·2008
    Same author

    Behavioral and physiological effects of a single injection of rat interferon-alpha on male Sprague-Dawley rats: a long-term evaluation.

    Brain research·2006
    Same author

    Testosterone cream available at CPS; gel approved by FDA.

    AIDS treatment news·2003
    Same author

    Fluconazole: Pfizer asked to lower Africa price.

    AIDS treatment news·2003
    Same journal

    New kind of antiretroviral, KP-1461; clinical trial recruiting. Interview with Stephen Becker, M.D.

    AIDS treatment news·2008
    Same journal

    Flu shot reminder.

    AIDS treatment news·2008
    Same journal

    AIDS search engine wanted: what to do now?

    AIDS treatment news·2007
    Same journal

    Is cure possible for HIV?

    AIDS treatment news·2007
    Same journal

    Financial accounts that can reproduce, inherit, and evolve.

    AIDS treatment news·2007
    Same journal

    Selling digital art in bulk through prepaid URLs.

    AIDS treatment news·2007
    See all related articles

    Structured treatment interruption in monkeys showed that specific immune responses helped maintain undetectable viral loads. Intermittent antiretroviral therapy led to better outcomes than continuous treatment upon permanent discontinuation.

    Area of Science:

    • Immunology
    • Virology
    • Primate Models

    Background:

    • Structured treatment interruption (STI) is an experimental approach in antiretroviral therapy (ART).
    • Understanding immune responses during STI is crucial for developing effective HIV management strategies.

    Discussion:

    • This study investigated the impact of STI on viral load and immune markers in a primate model.
    • Immune responses correlated with sustained viral control during treatment interruptions.

    Key Insights:

    • The first randomized controlled trial of STI demonstrated its feasibility in a non-human primate model.
    • Specific immune responses were associated with maintaining undetectable viral loads during ART interruptions.
    • Animals on intermittent ART showed improved outcomes compared to continuous ART upon permanent discontinuation.

    Related Experiment Videos

    Outlook:

    • Findings suggest STI could be a viable strategy for managing viral load in certain contexts.
    • Further research is needed to explore the long-term efficacy and safety of STI in humans.
    • Investigating the precise immune mechanisms underlying sustained viral control during STI is warranted.