Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics of dementia.

Debby W Tsuang1, Thomas D Bird

  • 1Departments of Psychiatry and Behavioral Sciences and Epidemiology, University of Washington, Seattle, WA, USA. dwt1@u.washington.edu

The Medical Clinics of North America
|August 13, 2002
PubMed
Summary

Advances in understanding the genetic basis of neurodegenerative diseases, particularly Mendelian inheritance patterns, are paving the way for new diagnostic and therapeutic strategies for cognitive disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In memoriam - Ming T. Tsuang, M.D., Ph.D., D.Sc.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

Acta neuropathologica·2026
Same author

Medication-Wide Association Study of Alzheimer's Disease and Related Dementias: Identifying Drug Candidates from Electronic Health Records through Explainable AI.

medRxiv : the preprint server for health sciences·2026
Same author

Variant Prioritization by Pedigree-Based Haplotyping.

Genetic epidemiology·2026
Same author

Drug Development.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Area of Science:

  • Neuroscience
  • Genetics
  • Medical Genetics

Background:

  • Neurodegenerative diseases are complex disorders with significant genetic underpinnings.
  • Rare families exhibit Mendelian inheritance of certain neurodegenerative conditions.
  • Recent decades have seen major advancements in understanding the genetic basis of these diseases.

Purpose of the Study:

  • To review the genetics of common neurodegenerative disorders associated with cognitive disturbances.
  • To highlight the role of identified causative genes in disease pathogenesis.
  • To discuss the clinical implications of genetic findings for future diagnostics and therapeutics.

Main Methods:

  • Review of genetic analyses of neurodegenerative disorders.
  • Identification and classification of families with Mendelian inheritance patterns.
  • Examination of causative gene mapping and mutation cloning.

Main Results:

  • Causative genes for several common neurodegenerative disorders with cognitive disturbances have been identified.
  • Genetic analysis is clarifying the role of genes in sporadic disease forms.
  • Understanding gene function offers insights into disease mechanisms.

Conclusions:

  • Molecular genetics has elucidated disease etiology.
  • Clinicians play a vital role in identifying and classifying affected families.
  • Future genetic discoveries promise new diagnostic and therapeutic strategies for dementing disorders.

Related Experiment Videos