Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interspecies comparisons for the C3-C4 propriospinal system: unresolved issues.

Peter A Kirkwood1, M A Maier, Roger N Lemon

  • 1Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, UK. pkirkwoo@ion.ucl.ac.uk

Advances in Experimental Medicine and Biology
|August 13, 2002
PubMed
Summary

Conflicting views exist on C3-C4 propriospinal neurons in macaques. Further research is needed to understand their function and connectivity before comparing them to cats or humans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left-right asymmetry in the thoracic spinal cord.

Neuroscience letters·2025
Same author

Terminal organization of the corticospinal projection from the arm/hand region of the rostral primary motor cortex (M1r or old M1) to the cervical enlargement (C5-T1) in rhesus monkey.

The Journal of comparative neurology·2023
Same author

The evidence against somatotopic organization of function in the primate corticospinal tract.

Brain : a journal of neurology·2022
Same author

Lack of somatotopy among corticospinal tract fibers passing through the primate craniovertebral junction and cervical spinal cord: pathoanatomical substrate of central cord syndrome and cruciate paralysis.

Journal of neurosurgery·2021
Same author

Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons.

Cerebral cortex (New York, N.Y. : 1991)·2021
Same author

The Cortical "Upper Motoneuron" in Health and Disease.

Brain sciences·2021

Area of Science:

  • Neuroscience
  • Spinal Cord Research

Background:

  • The functional significance of C3-C4 propriospinal neurons in macaques is debated.
  • Existing observations suggest this system is less prominent in macaques compared to cats.

Purpose of the Study:

  • To critically evaluate the current understanding of C3-C4 propriospinal neuron function in macaques.
  • To question the premature conclusions drawn from strychnine experiments regarding inhibition.

Main Methods:

  • Analysis of existing experimental data, including strychnine-induced observations.
  • Comparative neuroanatomy and physiology.

Main Results:

  • Observations from different laboratories, while conflicting, show similar patterns suggesting a weaker system in macaques.

Related Experiment Videos

  • Strychnine experiments suggest inhibition, but this interpretation may be premature.

    • Conclusions:

    • The functional importance of C3-C4 propriospinal neurons in macaques requires more extensive investigation.
    • Analogies with feline systems and implications for human studies should be approached with caution due to incomplete knowledge of macaque neuronal connectivity.