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Hydroxamic acids as pharmacological agents
E M F Muri1, M J Nieto, R D Sindelar
1Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS, 38677, USA.
Current Medicinal Chemistry
|August 13, 2002
Abstract:
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.