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Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy
Karin Malmqvist1, Håkan N Wallén, Claes Held
1Division of Internal Medicine, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden. karin.malmqvist@med.ds.sll.se
Journal of Hypertension
|August 13, 2002
Summary
Concentric left ventricular hypertrophy is linked to elevated soluble cell adhesion molecules and increased carotid artery intima-media thickness. This suggests vascular endothelium activation in hypertensive patients with this condition.
Area of Science:
- Cardiology
- Vascular Biology
- Hypertension Research
Background:
- Concentric left ventricular (LV) hypertrophy is a significant cardiovascular risk factor.
- Endothelial activation plays a role in cardiovascular disease pathogenesis.
Purpose of the Study:
- To investigate the association between concentric LV hypertrophy and vascular endothelium activation.
- To assess levels of soluble cell adhesion molecules (E-selectin, ICAM-1, VCAM-1) in hypertensive patients with different LV hypertrophy patterns.
Main Methods:
- Serum levels of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured.
- Carotid artery intima-media thickness (IMT) and LV mass were assessed.
- Neurohormone activities were also evaluated.
Main Results:
- Hypertensive patients with concentric LV hypertrophy exhibited higher E-selectin, ICAM-1, and VCAM-1 levels compared to those with eccentric hypertrophy.
- Concentric LV hypertrophy was associated with increased carotid artery IMT.
- E-selectin and VCAM-1 levels correlated positively with LV relative wall thickness.
Conclusions:
- Concentric LV hypertrophy is characterized by elevated soluble cell adhesion molecules and increased carotid artery IMT.
- These findings indicate vascular-level perturbations and endothelial activation in hypertensive patients with concentric LV hypertrophy.