[Chemotactic effects of some staphylococcal substances (author's transl)]

A Kleickmann, J Brückler, H Blobel

Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie

|October 1, 1975

Abstract:

Bovine leukocytes, besides rabbit leukocytes, were found to be suitable for chemotactic studies on staphylococci with the modified Boyden-method. The bovine leukocytes could be obtained more easily in larger quantities. Casein, however, had no significant chemotactic effects on bovine leukocytes. Culture supernatants of Staphylococcus aureus and S. epidermidis and the heat-killed staphylococci had cytotaxigenic and to a small degree also cytotaxic effects on the rabbit and bovine leukocytes. The extracted "straphylococcal skeletons", "clumping factor" (CF), protein A and capsular substances were cytotaxigenic. In addition, CF was moderately cytotaxic only for rabbit leukocytes. The chomotactic migration of leukocytes was markedly reduced after their treatment with leukocidin (PVL-R) in subleukocidic concentrations.

Keywords:

leukocyte chemotaxis staphylococcus aureus inflammatory response cell migration

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