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Congenital lumbosacral lipomas: pitfalls in analysing the results of prophylactic surgery
Neil L Dorward1, James H Scatliff, Richard D Hayward
1Department of Neurosurgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK.
Insights
Early and late presenting congenital lumbosacral lipomas may have different natural histories. Pre-operative urological assessment and MRI features predict surgical outcomes in children with these spinal cord conditions.
Area of Science:
- Pediatric Neurosurgery
- Spinal Cord Malformations
- Urological Outcomes
Background:
- Congenital lumbosacral lipomas are spinal cord malformations presenting with varied clinical histories.
- The natural history and predictive factors for surgical outcomes in early versus late presentations remain unclear.
Purpose of the Study:
- To investigate if early and late presentations of congenital lumbosacral lipomas follow the same natural history.
- To identify predictive factors for post-operative outcomes in surgically treated children.
Main Methods:
- A retrospective analysis of 50 consecutive surgically treated congenital lumbosacral lipoma cases.
- Pre- and post-operative urological assessments and magnetic resonance imaging (MRI) were utilized.
- Data on clinical presentation, follow-up, urological outcomes, and anatomical features were collected.
Main Results:
- A bimodal age distribution at presentation (0-2 and 7-8 years) was observed, with girls predominantly affected.
- Severe bladder dysfunction was more common in patients presenting at or after 3 years.
- Early surgery (before age 3) correlated with better outcomes; pre-operative assessment was a strong predictor of final urological status.
Conclusions:
- Early and late presenting groups may represent distinct patient cohorts with different natural histories.
- Large lipoma size and sacral positioning are associated with poorer urological outcomes.
- Pre-operative urological assessment and specific MRI findings are crucial for predicting surgical success in pediatric lumbosacral lipomas.
Objectives:
Our objectives were to examine the assumption that the natural history of congenital lumbosacral lipomas in children presenting early and those presenting late is the same, and to determine whether there are factors that might predict the post-operative outcome of surgery among the presenting features of children with lumbosacral lipomas.
Methods:
The authors present a clinical series of 50 consecutive cases of congenital lumbosacral lipoma that had been treated surgically. All patients underwent both pre- and post-operative urological assessment and pre-operative imaging with MRI. The case notes, urology assessments and MRI films were studied to provide data on the clinical presentation, follow-up history and urological outcome of the children, as well as on the anatomical features of their lipomas.
Results:
Analysis of the data revealed a predominance in girls and a bimodal distribution of age at presentation with peaks at 0-2 and 7-8 years. Skin stigmata were more frequent in children below 6 years of age than in older children (P=0.035). The MRI scans demonstrated that the conus lay within the sacral canal more often in girls than boys (P=0.025). Severe bladder dysfunction was significantly more frequent in those presenting at =3 years of age (P=0.017) and there were more normal outcomes in patients operated upon before the age of 3 than in those operated upon at or after this age ( P<0.0001). Eight patients who had been operated upon had severe urological problems at the time of their last assessment (median age of 8 years and 2 months). They were predominantly girls with major pre-operative urological dysfunction.
Conclusions:
Formal pre-operative urological assessment proved to be the strongest determinant of final urological outcome. Other predictors of poor urological outcome were large lipoma size and sacral position for the lipoma. This series demonstrates how early and late presenting children may represent different patient groups, follow different natural histories and may therefore not be reliable for comparison purposes. Future studies of prophylactic untethering need to follow cohorts beyond the age of deterioration found in untreated cases (8 years) and must report the salient MRI features that we suggest are predictive of poor outcome.
