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Infantile hepatic hemangioendothelioma presenting as early heart failure: report of two cases

Chung-Ching Lu1, Sheung-Fat Ko, Chi-Di Liang

  • 1Department of Pediatrics, Chang Gung Children's Hospital, Kaohsiung, Taiwan, ROC. Chung12025@yahoo.com.tw

Chang Gung Medical Journal
|August 14, 2002
PubMed

Insights

Infantile hepatic hemangioendothelioma can cause severe heart failure in infants. Early treatment with prednisolone or hepatic artery ligation effectively manages this rare condition, preventing fatal outcomes.

Area of Science:

  • Pediatric Oncology
  • Cardiology
  • Hepatology

Background:

  • Infantile hepatic hemangioendothelioma (IHH) is a rare liver tumor in infants.
  • It can present with life-threatening complications such as respiratory distress and congestive heart failure.

Observation:

  • Two infants with IHH experienced significant cardiorespiratory symptoms.
  • Serum alpha-fetoprotein (alphaFP) levels varied widely between the two cases.
  • One infant had extremely high alphaFP levels (26,343 microg/l), while the other had near-normal levels (18 microg/l).

Findings:

  • Prednisolone therapy in one infant and hepatic artery ligation in the other resulted in no residual sequelae after 12 months.
  • Both treatment modalities were effective in managing heart failure associated with IHH.
  • Early recognition and intervention are crucial for successful management.

Implications:

  • Prompt diagnosis and treatment of IHH complicated by heart failure can lead to favorable outcomes.
  • Prednisolone and hepatic artery ligation are viable therapeutic options for heart failure in IHH.
  • Differentiating IHH from hepatic malignancies is essential for appropriate clinical management.

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