Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

Protein Import into the Peroxisomes

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...

Amebiasis

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Introduction of a paediatric anaesthesia comic information leaflet reduced preoperative anxiety in children.

British journal of anaesthesia·2016

Same author

[Anticoagulation in acute phase of tandem vertebral dissection after thrombectomy of basilar artery occlusion: MRI contribution].

Revue neurologique·2015

Same author

Ultra-early transcranial sonographic detection of intracerebral rebleeding after aneurysmal subarachnoid haemorrhage.

Intensive care medicine·2015

Same author

Ultrasonographic anatomic variations of the major veins in paediatric patients.

British journal of anaesthesia·2014

Same author

Predicting fluid responsiveness in mechanically ventilated children under general anaesthesia using dynamic parameters and transthoracic echocardiography.

British journal of anaesthesia·2011

Same author

[Design and evaluation of the quality of information written for scanner and magnetic resonance imaging in neuropediatrics].

Annales francaises d'anesthesie et de reanimation·2010

Search research articles

Related Experiment Video

Updated: Jul 28, 2026

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

Peritoneal infection: a possible redox disease.

M Goldner¹, S Grousson, M Jourlin

¹Département de biologie médicale, Faculté de Médecine, Université Laval, Québec, Canada.

The New Microbiologica

|August 14, 2002

Summary

Bacteroides fragilis peritonitis invasion depends on oxidation-reduction (redox) potential. Bacteria penetrated HeLa cells under oxidizing conditions, but not reducing conditions, highlighting redox

Area of Science:

Microbiology
Cell Biology
Infectious Diseases

Background:

Bacteroides fragilis is an opportunistic pathogen.
Peritonitis is a serious infection, often involving anaerobic bacteria.
The invasive mechanisms of B. fragilis are not fully understood.

Purpose of the Study:

To investigate the role of oxidation-reduction (redox) potential in B. fragilis invasion of host cells.
To determine if environmental conditions influence bacterial penetration.

Main Methods:

Utilized 3D imaging techniques to visualize bacterial penetration.
Cultured B. fragilis under varying redox conditions (oxidizing and reducing).
Co-cultured bacteria with HeLa cell monolayers.

More Related Videos

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein

Published on: June 18, 2020

Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures

Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures

Published on: August 16, 2024

Related Experiment Videos

Last Updated: Jul 28, 2026

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

Published on: March 24, 2012

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein

Assessment of Cellular Oxidation using a Subcellular Compartment-Specific Redox-Sensitive Green Fluorescent Protein

Published on: June 18, 2020

Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures

Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures

Published on: August 16, 2024

Main Results:

B. fragilis grown under oxidizing (+mV redox) conditions successfully penetrated HeLa cell monolayers.
B. fragilis grown under reducing (-mV redox) conditions did not penetrate HeLa cells.
Demonstrated a clear correlation between redox potential and bacterial invasiveness.

Conclusions:

The oxidation-reduction (redox) potential is a critical factor influencing B. fragilis invasiveness.
Environmental flux between anaerobic and aerobic conditions may trigger bacterial invasion mechanisms.
Understanding redox-dependent invasion is crucial for managing B. fragilis infections.