cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity
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Updated: Sep 30, 2026

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
Published on: January 19, 2015
Chris Meiera1, Jürgen Renzea, Christian Ducho
1Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, Hamburg, D-20146, Germany. chris.meier@chemie.uni-hamburg.de
Abstract:
Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogues against different viral diseases. The basic idea is to achieve nucleotide delivery into cells, bypassing limitations with intracellular formation of nucleotides from their nucleoside precursors. The cycloSal-concept is one of several pronucleotide systems reported so far. For the nucleoside analogue d4T, the cycloSal-approach improved antiviral potency. The basic idea, chemistry, different structural modifications and their effects on the antiviral potency of the cycloSal-d4TMP triesters have been discussed in this review.
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