New trends in anti-malarial agents.

Area of Science:

• * Tropical medicine and infectious diseases.
• * Parasitology and drug discovery.

Background:

• * Malaria affects over 400 million people annually, causing over a million deaths, predominantly in young African children.
• * Increasing resistance of malaria parasites to antimalarial drugs and mosquito vectors to insecticides exacerbates the global health crisis.
• * Over half the world's population resides in malaria-risk areas, highlighting the urgent need for effective interventions.

Purpose of the Study:

• * To review established malaria treatments.
• * To present recent advancements in antimalarial drug discovery.
• * To highlight novel therapeutic agents, including artemisinin derivatives and peroxidic compounds.

Main Methods:

• * Literature review of classical and contemporary antimalarial therapies.
• * Analysis of scientific research on drug resistance in malaria parasites and vectors.
• * Examination of emerging antimalarial drug candidates.

Main Results:

• * Classical antimalarial treatments face challenges due to widespread drug resistance.
• * Artemisinin and its derivatives represent a significant advancement in malaria treatment.
• * Novel peroxidic compounds show promise as new antimalarial agents.

Conclusions:

• * The development of new antimalarial drugs is a critical global health priority.
• * Artemisinin derivatives and peroxidic compounds offer promising avenues for combating malaria.
• * Continued research is essential to overcome drug resistance and improve malaria control strategies.