[The antiparkinson activity of gludantan (preliminary report)]

A total of 33 patients with different forms of parkinsonism were treated by a new original antiparkinsonic preparation Gludantane synthesized at the Institute of Organic Synthesis of the Latvian Academy of Sciences. The authors demonstrated a higher antiparkinsonic activity of this drug compared to cholinolytical preparations and midantane and the possibility of achieving a better therapeutical effect in a combination of gludantane with other antiparkinsonic drugs. The preparation appeared to be effective in different etiological forms of parkinsonism. However, its highest effect was in the rigid and rigid-trembling forms, and less effective in trembling-rigid forms and not effective in the trembling form. Gludantane is practically devoid of side-effects and is well tolerated by patients.