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Angiolymphoid hyperplasia with eosinophilia: a classic clinical presentation with histologic features of angiosarcoma
Nathalie C Zeitouni1, Sameh Hanna, Thom R Loree
1Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. zeitouni@roswellpark.org
Background:
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease manifested by the proliferation of morphologically distinct endothelial cells.
Objective:
To illustrate by a case report the clinical and varied histopathologic findings of ALHE.
Methods:
A 29-year-old woman presented with a clinical picture of ALHE but had several histologic features of angiosarcoma.
Results:
Management of this patient included repeat biopsies of the lesions, excision of the involved areas, careful histologic examination of the entire specimen, and appropriate follow-up.
Conclusion:
ALHE may present with various histologic features. Knowledge of the spectrum of benign and malignant vascular neoplasms helps manage these challenging cases.