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Updated: Aug 19, 2026

Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Assessment of myocardial viability with myocardial contrast echocardiography
1Cardiovascular Division at the University of Virginia Medical Center, Charlottesville 22908, USA. jlindner@virginia.edu
Insights
Myocardial contrast echocardiography (MCE) assesses heart muscle viability noninvasively. This technique helps identify patients who may benefit from revascularization or therapies for left ventricular remodeling.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Noninvasive imaging is crucial for managing myocardial infarction and coronary artery disease.
- Assessing myocardial viability guides treatment decisions for revascularization and left ventricular remodeling.
- Microvascular integrity is key to maintaining myocellular viability.
Purpose of the Study:
- To evaluate the role of myocardial contrast echocardiography (MCE) in assessing myocardial viability.
- To determine the feasibility of routine MCE for patients with acute and chronic coronary artery disease.
Main Methods:
- Myocardial contrast echocardiography (MCE) uses microbubble agents for myocardial opacification via venous injections.
- MCE provides spatial assessment of myocardial perfusion, even with reduced blood flow or collateral dependence.
- The technique assesses microvascular integrity essential for myocellular viability.
Main Results:
- MCE accurately assesses the presence and extent of myocardial viability.
- The technique is effective in evaluating perfusion in conditions of severe epicardial stenoses or collateral-dependent beds.
- Routine MCE use is now feasible due to advancements in imaging technology and agents.
Conclusions:
- Myocardial contrast echocardiography is a valuable noninvasive tool for assessing myocardial viability.
- MCE aids in identifying patients who may benefit from revascularization or specific therapies.
- Further studies are needed to establish the utility of MCE in guiding treatment strategies.
Abstract:
The application of noninvasive imaging techniques to assess myocardial viability has become an important part of routine management of patients with acute myocardial infarction and chronic coronary artery disease. Information regarding the presence and extent of viability may help identify patients likely to benefit from revascularization or therapy directed at attenuating left ventricular remodeling. Myocardial contrast echocardiography (MCE) is capable of defining the presence and extent of viability by providing an accurate assessment of microvascular integrity needed to maintain myocellular viability. It is especially suited for the spatial assessment of perfusion, even when myocardial blood flow is reduced substantially in the presence of severe epicardial stenoses or in a bed dependent on collateral perfusion. The routine use of MCE to evaluate viability in patients with acute and chronic coronary artery disease is now feasible with the advent of new imaging technologies and microbubble agents capable of myocardial opacification from venous injections. The utility of this technique for determining treatment strategies has not been established but is forthcoming.
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