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Syntheses of Metal Phthalocyanines and Their Photoinactivations on Cancer Cells
Er-Sheng Liu1, Zhi-Fei Dai, Jian-Dong Huang
1Department of Chemistry, Institute of Functional Materials, Fuzhou University, Fuzhou 350002, China.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica
|August 14, 2002
Abstract:
This paper reported the syntheses of amphiphilic substituted metal phthalocyanines containig sulfonic acid groups and phthalimidomethyl groups (MPcSP, M=Zn or Al(OH), S=-SO(3)(-), P=phthalimidomethyl). We have selected zinc phthalocyanine (Zn-D) as the one with better cell killing potential by an in vitro cell survival assay. Over 90 % tumor cells were killed with 10 mg/L Zn-D, after they were exposed to 12 J/cm(2) red light.