Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Learning and memory in agmatine-treated rats.

B E McKay1, W E Lado, L J Martin

  • 1Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, ON, Canada P3E 2C6. bemckay@ucalgary.ca

Pharmacology, Biochemistry, and Behavior
|August 15, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corticosterone regulates the balance between freezing and rearing in defensive responses to predator threat.

Progress in neuro-psychopharmacology & biological psychiatry·2025
Same author

Further evidence of misclassification of the injury deaths in South Africa: When will the barriers to accurate injury death statistics be removed?

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023
Same author

South Africa's male homicide epidemic hiding in plain sight: exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations.

medRxiv : the preprint server for health sciences·2023
Same author

Opioid Use After Nephrectomy for Kidney Cancer in Ontario: A Population-Based Study.

Urology·2022
Same author

Local recommendations for death scene investigation of sudden unexpected death in infants (SUDI) based on prospective observations.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Factors Associated with Discontinuation of Active Surveillance among Men with Low-Risk Prostate Cancer: A Population-Based Study.

The Journal of urology·2021

Systemic agmatine administration selectively impairs contextual fear learning and conditioned taste aversion in rats. However, it does not affect spatial learning or auditory-cued fear memory, indicating specific memory system impacts.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Memory Research

Background:

  • Agmatine is a neurochemical with known interactions with the N-methyl-D-aspartate (NMDA) receptor.
  • Its precise role in various forms of learning and memory requires further elucidation.

Purpose of the Study:

  • To investigate the effects of systemically administered agmatine on different types of learning and memory in rats.
  • To determine if agmatine impacts spatial learning, fear conditioning (contextual and cued), and taste aversion learning.

Main Methods:

  • Male Wistar rats received varying doses of agmatine or saline prior to or after training sessions.
  • Behavioral tasks included the water maze (spatial learning), contextual and auditory-cued fear conditioning, and conditioned taste aversion.

Related Experiment Videos

  • Performance was assessed through measures like latency, probe trial preference, fear response during extinction, and taste aversion acquisition.

    • Main Results:

    • Agmatine did not impair water maze performance (spatial learning).
    • It dose-dependently impaired contextual fear learning but not auditory-cued fear learning.
    • Agmatine abolished conditioned taste aversion learning.

    Conclusions:

    • Systemically administered agmatine selectively impairs specific forms of learning and memory, particularly contextual fear and taste aversion.
    • Agmatine's effects appear specific to certain memory types, not global cognitive function or motor activity.
    • These findings suggest agmatine's potential role in modulating distinct neural pathways involved in memory consolidation.