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Related Experiment Videos

A novel particle engineering technology: spray-freezing into liquid.

True L Rogers1, Jiahui Hu, Zhongshui Yu

  • 1College of Pharmacy (Mailstop A 1920), University of Texas at Austin, Austin, TX 78712-1074, USA.

International Journal of Pharmaceutics
|August 15, 2002
PubMed
Summary

Spray-freezing into liquid (SFL) enhances drug dissolution. This novel particle engineering technique successfully produced micronized powders of poorly soluble drugs and stable peptide particles.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Poorly water-soluble drugs exhibit limited bioavailability.
  • Novel particle engineering techniques are needed to improve drug delivery.
  • Spray-freezing into liquid (SFL) is an emerging technology for particle formation.

Purpose of the Study:

  • To evaluate the efficacy of spray-freezing into liquid (SFL) for enhancing the dissolution rates of poorly water-soluble active pharmaceutical ingredients (APIs).
  • To produce stable peptide particles using the SFL process.

Main Methods:

  • The SFL process involves atomizing a feed solution containing an API and excipients beneath the surface of a cryogenic liquid (liquid nitrogen).
  • Atomized droplets rapidly solidify, forming microparticles in suspension.

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  • Collected microparticles are lyophilized to yield dry SFL micronized powder.

    • Main Results:

    • The SFL process successfully enhanced the dissolution rates of carbamazepine and danazol, two model poorly water-soluble APIs.
    • Stable peptide particles of insulin were produced using the SFL technique.
    • The SFL process yielded micronized powders with improved characteristics.

    Conclusions:

    • Spray-freezing into liquid (SFL) is a viable technology for improving the dissolution of poorly water-soluble APIs.
    • SFL enables the production of stable peptide particles, offering potential for peptide drug delivery.
    • This particle engineering approach holds promise for pharmaceutical formulation development.