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Biodegradation and drug release studies of BSA loaded gelatin microspheres
K Mladenovska1, E Kumbaradzi, G Dodov
1Institute of Pharmaceutical Technology, Department of Biopharmacy, Faculty of Pharmacy, University Ss Cyril and Methodious, Vodnjanska 17, 1000, Skopje, Macedonia.
Abstract:
Certain variations in the process parameters (emulsification time, surfactant concentration) were performed in order to prepare BSA-loaded gelatin microspheres with high loading efficacy and particle size ranging from 1 to 10 microm using a procedure originally employed by Tabata and Ikada. The mathematical modelling of drug release in the presence of collagenase showed a biphasic release pattern, where the rate constant for the initial time release confirmed the influence of the particle size and/or enzymatic degradation rate on drug release rate.