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Tremolite and mesothelioma.

Victor L Roggli1, Robin T Vollmer, Kelly J Butnor

  • 1Department of Pathology, Duke University and Durham VA Medical Centers, NC 27710, USA. roggli.v@durham.va.gov

The Annals of Occupational Hygiene
|August 15, 2002
PubMed
Summary

Tremolite asbestos contamination in talc and chrysotile products is linked to mesothelioma. This study quantifies tremolite fiber burden in mesothelioma patients, highlighting its significant role in asbestos-related diseases.

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Area of Science:

  • Environmental Health
  • Occupational Medicine
  • Mineralogy

Background:

  • Chrysotile asbestos exposure is linked to mesothelioma.
  • Contaminating tremolite fibers are implicated as the etiological factor in mesothelioma.
  • Tremolite also contaminates talc, a common mineral fiber in control cases.

Purpose of the Study:

  • To determine the content of tremolite, non-commercial amphiboles, talc, and chrysotile in lung tissue samples from mesothelioma cases.
  • To investigate the association between tremolite, talc, and chrysotile fiber burdens.

Main Methods:

  • Analysis of lung parenchyma fiber burden in 312 mesothelioma cases using scanning electron microscopy.
  • Quantification of tremolite, non-commercial amphiboles, talc, and chrysotile content.

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Main Results:

  • Tremolite was identified in 53% of cases, with elevated levels in 26%.
  • Fibrous talc was found in 62% of cases and strongly correlated with tremolite content (P < 0.0001).
  • Chrysotile was identified in 10% of cases, also correlating strongly with tremolite (P < 0.0001).

Conclusions:

  • Tremolite in mesothelioma victims' lungs originates from both talc and chrysotile sources.
  • Tremolite constitutes a significant portion of the excess fiber burden in asbestos product users.