Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial pathogen genomics and vaccines.

Richard Moxon1, Rino Rappuoli

  • 1Molecular Infectious Diseases Group, Weatherall Institute of Molecular Medicine and University of Oxford Department of Paediatrics, John Radcliffe Hospital, Oxford UK.

British Medical Bulletin
|August 15, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep-learning image analysis for high-throughput screening of opsono-phagocytosis-promoting monoclonal antibodies against Neisseria gonorrhoeae.

Scientific reports·2024
Same author

Primary cancer prevention for cancers with no known infectious etiology: Time for a new paradigm.

Vaccine·2024
Same author

Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody.

bioRxiv : the preprint server for biology·2024
Same author

High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines.

Vaccines·2023
Same author

Prior SARS-CoV-2 Infection Enhances Initial mRNA Vaccine Response with a Lower Impact on Long-Term Immunity.

ImmunoHorizons·2023

Genomic data accelerates the development of new bacterial vaccines, addressing unmet needs for diseases like tuberculosis. This approach enables a comprehensive strategy for identifying and creating effective vaccines against various bacterial pathogens.

Area of Science:

  • Microbiology
  • Vaccinology
  • Genomics

Background:

  • Bacterial infectious diseases cause significant global mortality and disability.
  • Existing vaccines are insufficient for many critical bacterial infections, including tuberculosis, gonorrhoea, and Helicobacter pylori-associated diseases.
  • The development of novel vaccines is crucial to combat these persistent health threats.

Purpose of the Study:

  • To highlight the transformative impact of complete bacterial genome sequencing on vaccine development.
  • To emphasize the need for advanced genomic and bioinformatics approaches in identifying novel vaccine candidates.
  • To underscore the importance of integrating genomics with population biology for broad-spectrum vaccine efficacy.

Main Methods:

  • Leveraging complete bacterial genome sequences to identify all potential vaccine candidates.

Related Experiment Videos

  • Utilizing adjunct technologies such as bioinformatics, random mutagenesis, microarrays, and proteomics for systematic vaccine discovery.
  • Integrating genomic data with population biology to ensure vaccines target all pathogenic strains.

    • Main Results:

    • Complete genome sequences provide a comprehensive resource for novel vaccine target identification.
    • Genomic approaches, combined with other technologies, enable a systematic and rapid vaccine development pipeline.
    • The successful application of genomics in Neisseria meningitidis group B vaccine development serves as a proof of principle.

    Conclusions:

    • Genomics has revolutionized the discovery and development of bacterial vaccines.
    • A comprehensive, genomics-driven approach is essential for creating effective vaccines against challenging bacterial pathogens.
    • Future vaccine development strategies must integrate genomic insights with population-level data for maximum impact.