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Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic

Aruna D Pradhan1, Nader Rifai, Paul M Ridker

  • 1Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115-1204, USA.

Circulation
|August 15, 2002
PubMed

Insights

Elevated soluble intercellular adhesion molecule-1 (sICAM-1) levels predict peripheral arterial disease (PAD) development in healthy men. This finding highlights sICAM-1 as a potential biomarker for early systemic atherosclerosis risk.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • Soluble cellular adhesion molecules are linked to coronary events.
  • The association with early systemic atherosclerosis is uncertain.

Purpose of the Study:

  • To investigate the relationship between soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and the development of symptomatic peripheral arterial disease (PAD).

Main Methods:

  • Prospective, nested case-control study of 14,916 middle-aged men.
  • Assessed baseline sICAM-1 and sVCAM-1 levels.
  • Followed participants for 9 years for PAD development.
  • Statistical analyses adjusted for risk factors.

Main Results:

  • Higher baseline sICAM-1 levels were observed in men who developed PAD (P=0.005).
  • Elevated sICAM-1 was significantly associated with increased PAD risk (OR 3.5, P=0.008) after adjustments.
  • sVCAM-1 levels were not associated with PAD development.

Conclusions:

  • Elevated sICAM-1 is an independent predictor of accelerated atherosclerosis.
  • sICAM-1 may serve as a biomarker for PAD risk in healthy men.
Abstract

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