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Updated: Sep 30, 2026

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Published on: June 30, 2022
Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast
Emmanuelle Fabre1, Bernard Dujon, Guy-Franck Richard
1Unité de Génétique Moléculaire des Levures (URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie) Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France. efabre@pasteur.fr
Abstract:
Trinucleotide repeats are involved in several neurological disorders in humans. DNA sequences containing CAG/CTG repeats are prone to slippage during replication and double-strand break repair. The effects of trinucleotide repeats on transcription and on nuclear export were analyzed in vivo in yeast. Transcription of a CAG/CTG trinucleotide repeat in the 3'-untranslated region of a URA3 reporter gene leads to transcription of messenger RNAs several kilobases longer than the expected size. These long mRNAs form more readily when CAG rather than CTG repeats are transcribed. CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases.
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Regulated mRNA Transport
Nuclear Export of mRNA
Transfer RNA Synthesis
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Transfer RNA Synthesis
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Transcription
Transcription
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

