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Updated: Sep 30, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
Published on: October 31, 2025
[Prophylaxis and therapy of gastropathy caused by non-steroidal anti-inflammatory drugs]
1Semmelweis Egyetem, Altalános Orvostudományi Kar, Kútvölgyi Klinikai Tömb, Budapest.
Introduction:
The main disadvantage of the nonsteroidal anti-inflammatory drugs (NSAID) is their toxic effect on the gastroduodenal mucosa, which can cause life-threatening complications.
Aims:
We discuss the possibilities to prevent the harmful effect of the NSAIDs: the use of safer NSAIDs, and the co-therapy with protective mechanisms.
Methods:
Among the safer NSAIDs we discuss the preferentially selective, and the highly selective COX-2 inhibitors, and the new, nitric-oxide releasing NSAIDs. We consider the role of the mucosa-protecting mechanisms: antacids, sucralfate, H2 receptor antagonists, proton-pump inhibitors, and misoprostol.
Conclusions:
The most effective opportunities to protect the gastroduodenal mucosa--which is highly recommended for the high risk group of patients--are the usage of highly selective NSAIDs, or the concomitant therapy with proton-pump inhibitors or misoprostol. The value of the letter is diminished by it's side effects.
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