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Related Experiment Videos

Antidepressants and neuroplasticity.

Carrol D'Sa1, Ronald S Duman

  • 1Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT, USA.

Bipolar Disorders
|August 16, 2002
PubMed
Summary
This summary is machine-generated.

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Antidepressants may help depression by boosting brain cell growth and survival pathways. This review explores how stress impacts brain structure and how medications promote neural plasticity.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pharmacology

Background:

  • Stress-induced brain structural impairments are observed in animals and humans with depression.
  • Understanding cellular changes is crucial for developing effective depression treatments.

Purpose of the Study:

  • To review literature on cellular changes linked to stress and depression.
  • To discuss how antidepressants induce adaptive plasticity and therapeutic effects.

Main Methods:

  • Literature review of clinical and basic research studies.

Main Results:

  • Antidepressant treatment increases adult hippocampal neurogenesis.
  • Antidepressants up-regulate cyclic adenosine monophosphate (cAMP) and neurotrophin signaling pathways.

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  • cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) are key mediators of antidepressant effects.

    • Conclusions:

    • Depression may involve disrupted neural plasticity and cell survival mechanisms.
    • Antidepressants may exert therapeutic effects by enhancing neurogenesis and modulating plasticity pathways.