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Gynecomastia and sexual impotence associated with methotrexate treatment
Maria Angeles Aguirre1, Antonio Vélez, Manuel Romero
1Servicio Reumatologia, Hospital Universitario Reina Sofía, Universidad de Córdoba, Spain. angelesaguirre@supercable.es
The Journal of Rheumatology
|August 16, 2002
Abstract:
Methotrexate (MTX) is the disease modifying antirheumatic drug most frequently used for rheumatoid and psoriatic arthritis (PsA). Several reports associate sexual dysfunction to MTX use. We describe 2 cases of sexual impotence and gynecomastia in patients with PsA treated with MTX. Although the mechanism underlying MTX induced sexual dysfunction is unknown, the potential consequences should be taken in account in view of the steady increase in the number of patients.