Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimizing parameters for terminating cortical afterdischarges with pulse stimulation.

Gholam K Motamedi1, Ronald P Lesser, Diana L Miglioretti

  • 1Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, U.S.A.

Epilepsia
|August 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of Statistical and Machine Learning Risk Prediction Models for Advanced Breast Cancers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Using Artificial Intelligence to Improve Timeliness of Follow-Up in Breast Cancer Screening.

Journal of the American College of Radiology : JACR·2026
Same author

Trends in Pediatric Imaging From 1997 to 2024 in an Integrated Health Care Setting.

Hospital pediatrics·2026
Same author

In what clinical settings are the MASAI trial results applicable?

Nature reviews. Clinical oncology·2026
Same author

CORE-VNS: Dosing and titration of VNS therapy in contemporary clinical practice.

Epilepsy & behavior reports·2026
Same author

Outcomes of Density-Targeted Supplemental Breast Magnetic Resonance Imaging Screening by Breast Cancer Risk: Long-Term Health and Economic Considerations.

Annals of internal medicine·2026
Same journal

Responsible use of artificial intelligence in peer-reviewed publications in epilepsy.

Epilepsia·2026
Same journal

Altered autonomic balance drives the increase in cardiac output and arterial pressure during convulsive seizures in nonanesthetized sheep.

Epilepsia·2026
Same journal

Diagnostic yield and copy number variants findings in 219 adult patients with developmental and epileptic encephalopathy.

Epilepsia·2026
Same journal

Prolonged fenfluramine use in open-label studies of Dravet or Lennox-Gastaut syndromes: Long-term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness.

Epilepsia·2026
Same journal

Electrocardiography characteristics and long-term mortality in people with epilepsy from a resource-poor community.

Epilepsia·2026
Same journal

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026
See all related articles

Brief pulses of electrical stimulation (BPS) are more effective at stopping afterdischarges (ADs) when applied directly to the stimulation site, early in the event, and to rhythmic ADs. These findings optimize BPS for seizure control.

Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Brief pulses of electrical stimulation (BPS) have shown potential in terminating cortical afterdischarges (ADs).
  • Understanding the optimal conditions for BPS efficacy is crucial for its clinical application in seizure management.

Purpose of the Study:

  • To investigate the specific conditions that enhance the effectiveness of BPS in suppressing ADs.
  • To identify parameters influencing the success rate of BPS in terminating seizure activity.

Main Methods:

  • Analysis of 200 afterdischarges (ADs) in seven patients with subdural electrodes.
  • Evaluation of BPS effectiveness based on stimulation site, timing, waveform characteristics, AD pattern, and onset latency relative to localization stimulus (LS).

Related Experiment Videos

Main Results:

  • BPS was 8.6 times more effective at primary stimulation sites compared to secondary sites.
  • Earlier BPS application (within 4.5s) and targeting the negative AD voltage peak increased efficacy (2x and 1.9x odds, respectively).
  • Rhythmic ADs and those not immediately following LS showed significantly better response rates to BPS.

Conclusions:

  • BPS is most effective for terminating ADs when applied directly to primary electrodes.
  • Early intervention and targeting specific phases of the AD waveform improve BPS success.
  • AD characteristics, such as rhythmic patterns and delayed onset, predict a better response to BPS therapy.