Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

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UDP-glucuronosyltransferase 1A9 function is mediated by the two C-terminal lysine residues and proper mobility/flexibility of the cytoplasmic tail.

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A conserved conformation-dependent mechanism for the TREK two-pore domain potassium channel inhibitors carvedilol and fluphenazine.

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High potency μ-opioid receptor agonists engage sodium-bound receptor states.

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Molecular basis for state-dependent drug block of Kv11.1 (human ether-à-go-go-related gene) potassium channels.

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Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

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Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

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