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Quantitative ultrasound and mortality: a prospective study.
Summary
Low quantitative ultrasound (QUS) predicts higher mortality in older women, independent of bone mineral density (BMD) and other risk factors. This suggests QUS may reflect aging processes beyond traditional measures.
Area of Science:
- Gerontology
- Osteoporosis Research
- Public Health
Background:
- Low bone mineral density (BMD) is linked to increased mortality.
- The association between quantitative ultrasound (QUS) and mortality remains unclear.
Purpose of the Study:
- To investigate the relationship between calcaneal QUS and mortality in older women.
- To compare the predictive value of QUS and BMD for mortality.
Main Methods:
- A cohort of 5816 women over 70 years old was studied.
- Calcaneal QUS and BMD were measured at baseline.
- Vital status was monitored for 5.0 years, with mortality causes classified.
Main Results:
- Women in the lowest QUS quintile exhibited the highest mortality.
- A 1 SD reduction in broadband ultrasonic attenuation (BUA) correlated with a 16% increase in mortality (RH=1.16).
- Low QUS was associated with increased mortality from cardiovascular disease, cancer, and other causes, though cancer association was not significant after adjustments.
Conclusions:
- Low QUS is a significant predictor of total and cause-specific mortality in older women.
- The association between QUS and mortality is independent of traditional risk factors.
- QUS may capture aging-related aspects not reflected by BMD or other health indicators.