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Related Experiment Videos

Morphine concentrations in plasma after intramuscular administration.

L Laitinen, J Kanto, M Vapaavuori

    British Journal of Anaesthesia
    |December 1, 1975
    PubMed
    Summary

    This study measured plasma morphine levels after intramuscular injection. Individual patient responses varied significantly, with no clear link between morphine concentration and pain relief.

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    Evaluation of mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 materials as API carriers for oral drug delivery.

    Drug delivery·2007

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Analytical Chemistry

    Background:

    • Preoperative medication is crucial for patient management.
    • Understanding drug pharmacokinetics, like morphine, is vital for optimizing therapeutic outcomes.
    • Radioimmunoassay provides a sensitive method for quantifying drug levels in biological samples.

    Purpose of the Study:

    • To quantify plasma morphine concentrations after intramuscular administration.
    • To investigate the pharmacokinetic variability of morphine in patients.
    • To explore the relationship between plasma morphine levels and pain relief.

    Main Methods:

    • Intramuscular administration of morphine at 0.2 mg/kg body weight.
    • Plasma morphine concentrations measured using radioimmunoassay.

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  • Data collected over 24 hours post-injection.

    • Main Results:

    • Peak plasma morphine concentrations occurred approximately one hour post-injection.
    • Significant inter-individual variation (sevenfold) in plasma morphine concentrations was observed.
    • Measurable morphine or its metabolites were detected in plasma for up to 24 hours.
    • No correlation was found between plasma morphine concentration and pain relief in patients undergoing therapeutic abortion.

    Conclusions:

    • Intramuscular morphine exhibits significant pharmacokinetic variability.
    • Current dosing may not consistently correlate with patient-reported pain relief.
    • Further research is needed to personalize morphine administration for effective pain management.