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Related Experiment Videos

Phycodnaviridae--large DNA algal viruses.

J L Van Etten1, M V Graves, D G Müller

  • 1Nebraska Center for Virology and Department of Plant Pathology, University of Nebraska, Lincoln, NE, U.S.A.

Archives of Virology
|August 16, 2002
PubMed
Summary

Large DNA viruses called phycodnaviruses infect algae. Genome sequencing of Paramecium bursaria chlorella virus (PBCV-1) and Ectocarpus siliculosus virus (EsV-1) reveals significant genetic differences due to their distinct lifestyles and ancient evolutionary divergence.

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Area of Science:

  • Virology
  • Genomics
  • Algal Biology

Background:

  • Phycodnaviridae are large, icosahedral, double-stranded DNA viruses infecting eukaryotic algae.
  • Genome sequencing has been completed for two prominent members: Paramecium bursaria chlorella virus (PBCV-1) and Ectocarpus siliculosus virus (EsV-1).

Purpose of the Study:

  • To compare the genomes of PBCV-1 and EsV-1.
  • To explore the biological properties and evolutionary divergence of phycodnaviruses.

Main Methods:

  • Genome sequencing of PBCV-1 and EsV-1.
  • Comparative genomic analysis to identify shared and unique genes.
  • Literature review of phycodnavirus biological properties.

Main Results:

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  • PBCV-1 (331 kb) has ~375 protein-encoding genes and 11 tRNA genes; EsV-1 (336 kb) has ~231 protein-encoding genes.
  • Only 33 genes are shared between PBCV-1 and EsV-1, with 17 having no known database counterparts.
  • Significant genomic differences correlate with their distinct life cycles (lytic freshwater vs. lysogenic marine) and ancient evolutionary origins.

    • Conclusions:

    • The low gene homology between PBCV-1 and EsV-1 highlights the impact of divergent lifestyles and evolutionary history on viral genome composition.
    • Phycodnaviruses possess ancient genes, allowing for substantial evolutionary diversification.