B-1 B cell subset composition of DBA/2J mice

Studies of B cell subpopulations have focused upon BALB/c mice and related strains. The B cell subset composition of DBA/2J mice, a prototype strain for BALB/c mice, has been investigated less thoroughly. This report provides the results of a study of the B-1 B cells of DBA/2J mice. In contrast to C.B-17 mice, in which B-1 B cells expressed both the CD5 and CD11b antigens, CD11b expression was most characteristic of DBA/2J B-1 B cells. This was particularly evident in the peritoneal cavity where CD5-CD11b+ B cells were the predominant B cell subpopulation. The number of B-1 B cells increased with age in both the spleen and peritoneal cavity. Strain-specific differences in B cell subset composition may be significant when considering B cell lymphomagenesis with aging.