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An amphiphilic resin-supported palladium catalyst for high-throughput cross-coupling in water
Yasuhiro Uozumi1, Yasushi Nakai
1Institute for Molecular Science and The Graduate University for Advanced Studies, Nishi-Gonaka 38, Myodaiji, Okazaki 444-8585, Japan. uo@ims.ac.jp
Organic Letters
|August 17, 2002
Abstract:
[reaction: see text] The Suzuki-Miyaura coupling of aryl halides (8 varieties) and aryl- or vinylboronic acids (12 varieties) took place in water in the presence of a palladium complex of an amphiphilic polystyrene-poly(ethylene glycol) copolymer resin-supported N-anchored 2-aza-1,3-bis(diphenylphosphino)propane ligand and potassium carbonate to give uniform and quantitative yields of the corresponding biaryls (96 varieties).