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Synthesis and self-inclusion of bipyridine-spaced cyclodextrin dimers
Hubertus F M Nelissen1, Martinus C Feiters, Roeland J M Nolte
1Department of Organic Chemistry, Nijmegen Science Research Institute of Matter, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
The Journal of Organic Chemistry
|August 17, 2002
Abstract:
The synthesis and conformational behavior of two cyclodextrin dimers containing aromatic bipyridine spacers is presented. The proton NMR spectra of these dimers in aqueous solution show a doubling of signals in the aromatic region due to complete or partial self-inclusion of the spacer. The degree and the strength of self-inclusion is dependent on the substitution pattern of the bipyridine unit. This unexpected difference in the self-inclusion behavior is revealed by 2D NOESY and circular dichroism spectra.