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Updated: Aug 3, 2026
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On-Chip Endothelial Inflammatory Phenotyping
Published on: July 22, 2012
Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis
Charles Q Meng1, Patricia K Somers, Carolyn L Rachita
1AtheroGenics, Inc., 8995 Westside Parkway, GA 30004, Alpharetta, USA. cmeng@atherogenics.com
Bioorganic & Medicinal Chemistry Letters
|August 17, 2002
Abstract:
A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.
