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4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Emmanuel Pinard1, Alexander Alanine, Anne Bourson
1Pharma Division, Discovery Chemistry, F. Hoffmann-La Roche Ltd., CH-4070, Basel, Switzerland. emmanuel.pinard@roche.com
Bioorganic & Medicinal Chemistry Letters
|August 17, 2002
Abstract:
Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.