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Updated: Sep 29, 2026

Fear Incubation Using an Extended Fear-Conditioning Protocol for Rats
Published on: August 22, 2020
Mechanisms of Pavlovian fear conditioning: has the engram been located?
1Center for Molecular and Behavioral Neuroscience, Aidekman Research Center, Rutgers State University, 197 University Avenue, Newark, NJ 07102, USA. pare@axon.rutgers.edu
Abstract:
Uncertainty persists as to whether the amygdala is a crucial site of plasticity for classically conditioned fear or merely a sensory relay to structures generating fear responses. A recent Nature study suggests that associative synaptic changes take place in neurons of the amygdala during fear conditioning, and that these changes require dopamine-mediated modulation. Nevertheless, these findings do not prove that the amygdala is a sufficient site of plasticity for fear memory.
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