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Updated: Aug 8, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity
Corinne J Hackbarth1, Dawn Z Chen, Jason G Lewis
1Versicor, Inc., Fremont, California 94555, USA.
Abstract:
Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at the P(1)' site. Using a combination of iterative parallel synthesis and traditional medicinal chemistry, we have identified a new class of PDF inhibitors with N-alkyl urea at the P(1)' site. Compounds with MICs of
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