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Updated: Aug 16, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Beta-1,2-mannosylation of Candida albicans mannoproteins and glycolipids differs with growth temperature and serotype
P A Trinel1, T Jouault, J E Cutler
1Laboratoire de Mycologie Fondamentale et Appliquée, INSERM EPI 9915, Faculté de Médecine, Pôle Recherche, 59045 Lille Cedex, France.
Abstract:
Increasing the growth temperature from 28 to 37 degrees C reduced the expression of beta-1,2-oligomannoside epitopes on mannoproteins of Candida albicans serotypes A and B. In contrast, beta-1,2-mannosylation of phospholipomannan (PLM) remained constant despite a slight decrease in the relative molecular weight (M(r)) of this compound. At all growth temperatures investigated, serotype A PLM displayed an M(r) and an antigenicity different from those of serotype B PLM when they were tested with a panel of monoclonal antibodies.
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