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Related Experiment Videos

Immunization in children with chronic renal failure.

Guido F Laube1, Christoph Berger, Philippe Goetschel

  • 1Nephrology Unit, University Children's Hospital, Zurich, Switzerland.

Pediatric Nephrology (Berlin, Germany)
|August 20, 2002
PubMed
Summary

Pediatric patients on dialysis or post-renal transplant showed high immunization rates and detectable antibodies. Despite a few infections, vaccination by the renal team proved effective in protecting these vulnerable children.

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Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Transplantation

Background:

  • Children on immunosuppression, particularly after organ transplantation, are at high risk for infections.
  • Routine immunization is crucial for protecting healthy children, but its efficacy in immunocompromised pediatric populations requires careful evaluation.

Purpose of the Study:

  • To assess the immunization rate and effectiveness in pediatric patients undergoing dialysis and renal transplantation.
  • To analyze the impact of a dedicated renal unit in administering vaccinations and monitoring antibody responses.

Main Methods:

  • Retrospective analysis of clinical data, vaccination records, and serum antibody titers in 62 children (1987-2000).
  • Vaccinations administered by the renal unit included diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella, hepatitis B, influenza, Hemophilus influenzae type b, varicella, and Streptococcus pneumoniae.

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Main Results:

  • All 62 patients received standard vaccinations; influenza and H. influenzae type b vaccines were introduced later. Varicella and S. pneumoniae vaccines were given to specific subgroups.
  • All vaccinated patients demonstrated detectable serum antibodies against the administered vaccines.
  • Three infections occurred post-vaccination: one varicella case and two peritonitis episodes (H. influenzae, S. pneumoniae) in a patient on peritoneal dialysis.

Conclusions:

  • A high immunization rate was achieved through monitoring and administration by the renal team.
  • The study suggests vaccination is effective, evidenced by antibody titers and low infection rates, though a few breakthrough infections indicate the need for ongoing vigilance.