Related Experiment Video
Updated: Jul 31, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
Published on: March 30, 2020
[Management of encapsulated blebs after glaucoma drainage device surgery]
T Gracía García-Miguel1, E Gutiérrez Díaz, M Montero Rodríguez
1Servicio de Oftalmología del Hospital 12 de Octubre, Madrid, España.
Purpose:
We analyse the different options for the management of encapsulated blebs after glaucoma drainage device surgery, specially subconjunctival 5-fluouracil (5-FU) injections with or without associated needling.
Methods:
Retrospective review of 20 eyes with encapsulated blebs following glaucoma drainage device surgery. All of the eyes received topical corticosteroids associated to digital massage. Subconjunctival 5-FU was necessary in 10 eyes, associated to needling of the bleb in 5 of them and to capsule excision in 2.
Results:
Fifteen eyes were considered successes (complete in 10 eyes and uncomplete in 5). Eight of them had been treated with 5-FU (80% success in the 5-FU treated eyes group), associated to needling and/or capsule excision in 4 of them. The remaining 7 eyes were only treated conservatively (70% success with corticoid therapy and digital pressure).
Conclusions:
We have obtained in our study very good results using subconjunctival 5-FU injections, associated in complicated or refractory cases to needling revision, in eyes with encapsulated blebs after glaucoma drainage device surgery, with no major complications (Arch Soc Esp Oftalmol 2002; 77: 429-434).
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment

