Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid hormone transporters: recent advances.

Takaaki Abe1, Takehiro Suzuki, Michiaki Unno

  • 1Division of Nephrology, Endocrinology and Vascular Medicine, Dept Medicine, Tohoku University Graduate School of Medicine and PRESTO, Japan Science and Technology Corporation (JST), Japan. takaabe@mail.cc.tohoku.ac.jp

Trends in Endocrinology and Metabolism: TEM
|August 21, 2002
PubMed
Summary

Thyroid hormones enter cells via specific transporters, not just passive diffusion. These organic anion transport systems, influenced by ion conditions and co-transporting anions, are key to hormone action.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Author Reflections: Preceding Systemic Chemotherapy Might Provide Better Prognosis for Pancreatic Ductal Adenocarcinoma with Positive Peritoneal Cytology.

Annals of surgical oncology·2021
Same author

Preceding Systemic Chemotherapy for Patients with Pancreatic Ductal Adenocarcinoma with Positive Peritoneal Cytology Provides Survival Benefit Compared with Up-Front Surgery.

Annals of surgical oncology·2021
Same author

Salvage esophagectomy for local recurrent esophageal cancer after definitive chemoradiotherapy followed by photodynamic therapy: A case report.

International journal of surgery case reports·2021
Same author

Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020: (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012).

Journal of hepato-biliary-pancreatic sciences·2021
Same author

Bleeding from jejunal varices formed at the Roux-en-Y jejunum site caused by the compression of the left renal vein after living donor liver transplantation with renoportal anastomosis.

Surgical case reports·2021
Same author

A case of esophageal achalasia presenting with empyema and septic shock differentiated from esophageal rupture.

Clinical journal of gastroenterology·2021

Area of Science:

  • Endocrinology
  • Cell Biology
  • Molecular Biology

Background:

  • Thyroid hormones were traditionally believed to enter cells via passive diffusion due to their hydrophobic nature.
  • Recent research reveals specific transport systems are involved in thyroid hormone uptake and release.

Purpose of the Study:

  • To discuss the classification of thyroid hormone transporters.
  • To highlight the influence of ionic environment on transporter function.
  • To identify co-transported organic anions.

Main Methods:

  • Molecular characterization of genes encoding thyroid hormone transporters.
  • Analysis of transporter activity under varying ionic conditions.

Main Results:

Related Experiment Videos

  • Numerous organic anion transport systems identified, with about half transporting thyroid hormones.
  • Thyroid hormone transporter classification is influenced by ionic milieu.
  • Specific organic anions are symported by these transporters.

Conclusions:

  • Thyroid hormone transport is mediated by specific organic anion transporters.
  • Understanding these transporters is crucial for comprehending thyroid hormone regulation and action.