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Interferon-alpha induced transient thyroid dysfunction in hepatitis C.

S Fernández-Díez1, J L Rodríguez-Agulló, M J Cascudo Rielo

  • 1Gastroenterology Unit, Hospital Clínico San Carlos, Madrid, Spain. sfernandezd@medynet.com

Revista Espanola De Enfermedades Digestivas
|August 21, 2002
PubMed
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Thyroid dysfunction, including hyperthyroidism and hypothyroidism, can occur during combination therapy for chronic hepatitis C. This condition was managed with thyroxine replacement, allowing treatment to continue successfully.

Area of Science:

  • Endocrinology
  • Hepatology
  • Immunology

Background:

  • Chronic hepatitis C infection is often treated with combination therapy.
  • Interferon and ribavirine are standard treatments for hepatitis C.
  • Hepatitis C virus (HCV) infection is associated with autoimmune phenomena.

Observation:

  • A 36-year-old female patient developed thyroid dysfunction during combination therapy for chronic hepatitis C.
  • The patient initially experienced hyperthyroidism, followed by hypothyroidism.
  • Thyroid dysfunction required thyroxine replacement therapy.

Findings:

  • Combination therapy with interferon and ribavirine was continued despite thyroid dysfunction.
  • The patient achieved a sustained biochemical and virological response to treatment.

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  • The autoimmune thyroid disorders observed were reversible with management.

    • Implications:

    • Thyroid dysfunction is a potential side effect of interferon-based hepatitis C treatment.
    • Management of thyroid dysfunction allows for successful completion of hepatitis C therapy.
    • Further research is needed to clarify the pathogenesis of autoimmune diseases in HCV patients undergoing interferon therapy.