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Apoptosis: an ocular perspective.

Sudarshan Khokhar1, Rohan Chawla

  • 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi. skhokhar38@hotmail.com

The National Medical Journal of India
|August 21, 2002
PubMed
Summary
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Apoptosis, a controlled cell death, is vital for development and tissue homeostasis. Understanding its mechanisms allows for therapeutic strategies targeting various diseases, including those affecting the eye.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Apoptosis is a fundamental biological process of programmed cell death, distinct from necrosis.
  • It is crucial for development, tissue homeostasis, and eliminating damaged cells in multicellular organisms.
  • Dysregulation of apoptosis is implicated in numerous physiological and pathological conditions.

Purpose of the Study:

  • To review the identification methods for apoptosis.
  • To explore molecular mechanisms and therapeutic strategies for controlling apoptosis.
  • To highlight the role of apoptosis in ocular development and disease.

Main Methods:

  • Identification of apoptosis through various techniques including electron microscopy, DNA fragmentation analysis, TUNEL assay, flow cytometry, and enzyme assays.

Related Experiment Videos

  • Review of molecular mechanisms involving specific genes and signaling pathways.
  • Analysis of therapeutic approaches targeting apoptotic pathways.

    • Main Results:

    • Apoptosis can be reliably detected using a range of established laboratory methods.
    • Numerous genes and molecular pathways govern the apoptotic process.
    • Therapeutic interventions aimed at modulating apoptosis are under development.

    Conclusions:

    • Apoptosis is a critical, tightly regulated process with broad physiological and pathological relevance.
    • Targeting apoptosis offers promising therapeutic avenues for a spectrum of diseases.
    • Further research into apoptosis modulation holds significant potential for treating ocular conditions.