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Updated: Sep 29, 2026

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
08:11

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors

Published on: May 19, 2010

Notch1 control of oligodendrocyte differentiation in the spinal cord

Stephane Genoud1, Corinna Lappe-Siefke, Sandra Goebbels

  • 1Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.

The Journal of Cell Biology
|August 21, 2002
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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