Assisted reproductive technologies: toward improving implantation rates and reducing high-order multiple gestations

Despite striking progress in reproductive medicine over the past quarter century, the number of high-order multiple gestations are unacceptably high, largely as a result of the drive to maintain pregnancy rates in a competitive range. Morphologic criteria are currently used to define the reproductive competence of individual embryos but are imperfect predictors of implantation potential. Current and potential strategies to improve the selection of embryos are described. By the use of several of these approaches, it is hoped that the overall number of embryos that are transferred will be reduced, thereby also reducing the multiple gestation rate.