[Mutagenic activity of psychotropic drugs]

Mutagenic activity of 33 psychotropic drugs was studied in Drosophila metanogaster according to the CLB method. The drugs are the following: leponex, neuleptil, randolectil, teralen, chlorprotixen, TPS-23, navane, pimosid, difenisid, rudotel, eunoktin, radedorm, meprobamat, trioxasin, elenium, napoton, aponal, lorasepam, nuredal, oxyphenonat, safrasin, surmantil, amitriptilin, prothioden, melipramin, saroten, tegretol, phenobarbital, diakarb, benzonal, suksilep, morpholep, sydnocarb. The increase in the mutation rate was induced by leponex (1.37% in adults and 1.21% in larvae), difenisid (1.18% in adults), two forms of the same drug eunoktin and radedorm (about 1.6% in adults), safrasin (1.06% in imago), saroten (1,36% in imago), phenobarbital (2.02% in imago). Even a slight increase of mutagenicity of widely spread psychotropic drugs is a very serious factor which needs further investigation and specification in other models and organisms.